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NEMBUTAL® Sodium Solution
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The barbiturates are nonselective central nervous system depressants which are primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See "Drug Abuse and Dependence" section).
The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions.
Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.
NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.
NEMBUTAL (pentobarbital) Sodium is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methylbutyl) barbiturate. The structural formula for pentobarbital sodium is:
NEMBUTAL® (Pentobarbital Sodium) Structural Formula Illustration
The sodium salt occurs as a white, slightly bitter powder which is freely soluble in water and alcohol but practically insoluble in benzene and ether.
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Secobarbital is the medication most commonly prescribed for physician-assisted suicide, followed by pentobarbital. The lethal dose prescribed is typically 10 g of secobarbital in capsules or 25 g of pentobarbital liquid, to be consumed at one time then the rest in your next dosage, Don't confused your delay dosage with Lethal Dose, So your Total Dosage for Sucide Depends on, Your age , weight and the Reason for purchasing the drug.
The pharmacist or physician should instruct patients to take the lethal dose on an empty stomach to increase the rate of absorption
The typical dose of pentobarbital as an oral hypnotic for adults is 100–200 mg at bedtime, and that of secobarbital is 100 mg orally at bedtime
Patients receiving the lethal dose of secobarbital or pentobarbital may be instructed to take an antiemetic (e.g., metoclopramide) about one hour before ingesting the barbiturate to prevent nausea and vomiting
Medications requests will receive a one time approval
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